When the show won the People's Choice Award in 2003, Angus T. Jones (Jake) accepted it on behalf of the cast and crew.
Blythe Danner was the original choice for Charlie and Alan's mother, and even started rehearsing with the cast. But she reluctantly had to drop out due to other conflicts.
At a convention of television critics during the summer of 2005, executive producer Chuck Lorre confirmed that the show's opening tune is performed by studio musicians and not by actors Charlie Sheen, Jon Cryer and Angus T. Jones (who merely lip-sync the lyrics). One of the actual crooners is singer and voice-over artist Elizabeth Daily.
The fridge in the set kitchen is actually functioning, which is unusual for television shows.
Each episode derives its title from a line in the working script.
Alan's Alimony is $3875 dollars a month.
April Bowlby made ten appearances as a guest star in season three. However, when she got bumped up to regular cast member status in season four, she only appeared five times.
Berta was originally supposed to be a recurring character, but Conchata Ferrell proved to be such a hit with the audience, that she became a regular cast member at the start of season two.
Rose was originally written off near the end of season four by having her move to London, because Melanie Lynskey had landed a part on the FOX pilot, "Drive" (2007) When that show was canceled, she was allowed to return to Two and a Half Men.
It's never mentioned as to what Judith does for a living. Alan is a chiropractor, Charlie is a jingle writer, Evelyn sells real estate, Berta is a housekeeper, Kandi is an actress, and Rose sits on the board of directors at her father's bank.