When the show won the People's Choice Award in 2003, Angus T. Jones (Jake) accepted it on behalf of the cast and crew.
Blythe Danner was the original choice for Charlie and Alan's mother, and even started rehearsing with the cast. But she reluctantly had to drop out due to other conflicts.
At a convention of television critics during the summer of 2005, executive producer Chuck Lorre confirmed that the show's opening tune is performed by studio musicians and not by actors Charlie Sheen, Jon Cryer and Angus T. Jones (who merely lip-sync the lyrics). One of the actual crooners is singer and voice-over artist Elizabeth Daily.
The fridge in the set kitchen is actually functioning, which is unusual for television shows.